Xanthosine monophosphate

Xanthosine monophosphate
IUPAC name

5'-xanthylic acid
Other names

xanthine ribotide,
XMP
Identifiers
CAS number 523-98-8
PubChem 122280
MeSH Xanthosine+monophosphate
Properties
Molecular formula C10H13N4O9P
Molar mass 364.206 g/mol
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Xanthosine monophosphate is an intermediate in purine metabolism. It is a ribonucleoside monophosphate. It is formed from IMP via the action of IMP dehydrogenase, and it forms GMP via the action of GMP synthase.

Clinical significance

Xanthylic acid can be used in quantitative measurements of the inosine monophosphate dehydrogenase enzyme activities in purine metabolism, as recommended to ensure optimal thiopurine therapy for children with acute lymphoblastic leukaemia (ALL).[1]

See also

References

  1. ^ Khalil PN, Erb N, Khalil MN, Escherich G, Janka-Schaub GE (September 2006). "Validation and application of a high-performance liquid chromatographic-based assay for determination of the inosine 5'-monophosphate dehydrogenase activity in erythrocytes". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 842 (1): 1–7. doi:10.1016/j.jchromb.2006.04.040. PMID 16725387. http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(06)00373-4. 
Purine metabolism
Anabolism

R5P→IMP: R5P · PRPP · PRA · GAR · FGAR · FGAM · AIR · CAIR · SAICAR · AICAR · FAICAR

IMP→AMP: Adenylosuccinate

IMP→GMP: Xanthosine monophosphate
Catabolism
Pyrimidine metabolism
Anabolism
Catabolism

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/i